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UROKINASE


Other Product Description
VEGF-165
Aprotinin
Urokinase
Prourokinase Non-glycosylated
Prourokinase Glycosylated
ATF
ATF II
Tissue Plasminogen
Activator

Glu-plasminogen
Lys-plasminogen
Plasmin
ETI

rEK

K2tPA

 

 

DESCRIPTION:
Urokinase (UK) is a serine protease which is one of biological plasminogen activators. It is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. It can be obtained from human urine or kidney cell culture. UK is a two chain glycoprotein containing 411 amino acids with 12 dissulfide bonds. Its molecular weight is 54,000.

SOURCE:
Human urine

PURITY:
Greater than 90% high molecular weight UK by SDS-PAGE.

SPECIFIC ACTIVITY:
Greater than 100,000 IU/mg.

ACTIVITY:
1 nM UK will cause a change in absorbance of 0.001 at 405 nm in 1 minute at room temperature in 100 ul 0.05 M Tris-HCl, 0.1 M NaCl, pH 7.4, using S2444 (0.6 mM) as the substrate.

PRESENTATION:
White lyophilized powder or solution.

STORAGE:
The lyophilized powder, though stable at room temperature, is best stored desiccated below 0C. It is soluble in water or other buffered solution.


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