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LYS-PLASMINOGEN


Other Product Description
VEGF-165
Aprotinin
Urokinase
Prourokinase Non-glycosylated
Prourokinase Glycosylated
ATF
ATF II
Tissue Plasminogen
Activator

Glu-plasminogen
Lys-plasminogen
Plasmin
ETI

rEK

K2tPA

 

 

DESCRIPTION:
Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.0 uM. Plasminogen can be activated to plasmin via t-PA, u-PA or streptokinase, resulting in hydrolysis of the Arg-560-Val-561 peptide bond, yielding two chains which remain covalently associated by a dissulfide bond. Lys-plasminogen is purified from Glu-plasminogen after restricted digestion by plasmin. The reaction results in the release of a 76 residue peptide (Glu-1-Lys-76). The molecular weight of Lys-plasminogen is 83,000.

SOURCE:
Human plasma that has been shown by certified tests to be negative for HBsAg and for HIV antibodies.

PURITY:
Single band by SDS-PAGE. Plasmin activity is not detectable. Lys-plasminogen is verified by acid-urea gel electrophoresis.

ACTIVITY:
After activation by urokinase, 1 nM plasmin will cause a change in absorbance of 0.001 at 405 nm in 1 minute at room temperature in 100 ul 0.05 M Tris-HCl, 0.1 M NaCl, pH 7.4, using S2251 (1.5 mM) as the substrate.

PRESENTATION:
Solution in 0.05 M Tris-HCl, 0.1M NaCl, pH 7.4

STORAGE:
It should be stored at -20 C. Avoid freeze/thaw cycles.


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