logoLANDING BIOTECH INC

Fax: 617-964-1187

EMAIL: sales@landingbiotech.com



Erythrina Trypsin Inhibitor (ETI)


Other Product Description
VEGF-165
Aprotinin
Urokinase
Prourokinase Non-glycosylated
Prourokinase Glycosylated
ATF
ATF II
Tissue Plasminogen
Activator

Glu-plasminogen
Lys-plasminogen
Plasmin
ETI

rEK

K2tPA

 

 

DESCRIPTION:
Erythrina trypsin inhibitor (ETI) was a single chain protein that contains 172 amino acids, including two disulfide bridges. ETI resembles the Kunitz-type protease inhibitors and has a high structural and sequence homology with soybean trypsin inhibitor (STI). Unlike STI and other members from Kunitz-type protease inhibitor family, ETI has been shown a strong inhibition against the activity of tissue plasminogen activator (tPA). ETI also inhibit trypsin and plasmin, while it has little effect on chymotrypsin, thrombin and urokinase. The active site of ETI is Arg64-Ser65. When coupled to sepharose, the ETI is an effective reagent for affinity purification of tPA, as well as the separation of single-chain and two-chain tPA. The molecular weight of ETI is 19,000 dalton.

SOURCE:
ERYTHRINA CAFFRA

PURITY:
Greater than 95% by SDS-PAGE

ACTIVITY:
The IC50 values for tPA and trypsin were 1.7x10 -7 M and 7.2x10-10 M, respectively. The specific inhibitory activity against tPA and trypsin were 1.5x109 unit/mmol and 2.4x1012 unit/mmol, respectively.

PRESENTATION:
White lyophilized powder or solution

STORAGE:
The lyophilized powder is best stored desiccated below 0 C. After it is reconstituted with sterile water or other buffered solutions, it should be stored at 4 C or -20 C.


|Main Page |Top of the Page | Send us an Email |