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Reteplase (K2tPA)


Other Product Description
VEGF-165
Aprotinin
Urokinase
Prourokinase Non-glycosylated
Prourokinase Glycosylated
ATF
ATF II
Tissue Plasminogen
Activator

Glu-plasminogen
Lys-plasminogen
Plasmin
ETI

rEK

K2tPA

 

 

DESCRIPTION:
Reteplase, or K2tPA, is a non-glycosylated deletion mutant variant of human tissue plasminongen activator (tPA) produced by E.coli using recombinant technology. Reteplase is made up of 355 amino acids, including amino acids 1-3 and 176-527 of native tPA. Reteplase consists of the kringle2 and the protease domain of tPA and has a moderate affinity for fibrin. In the presence of fibrin, plasminogen activation by Reteplase can be promoted. The molecular weight of Reteplase is 39571 daltons.

SOURCE:
E.coli.

PURITY:
Greater than 90% by SDS-PAGE.

ACTIVITY:

After conversion to two-chain form completely, 1 nM Reteplase will cause a change in absorbance of 0.001 at 405 nm in 1 minute at room temperature in 100 ml 50mM  Tris-HCl, 100mM NaCl, pH 7.4, using S2288 (0.6 mM) as the substrate.

 

PRESENTATION:

White lyophilized powder or solution.


STORAGE:
The lyophilized powder is best stored desiccated below 0C.


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